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The Ultimate Southern Italy Road Trip: Routes, Sights, Guides, Maps And More

From the vibrant city of Naples and the awe inspiring views of the Amalfi Coast, to the traditional Italian towns of Puglia and Sicily’s beaches, volcanoes and cuisine, it’s time to plan the ultimate southern Italy road trip! 

When it comes to road trips, a journey through southern Italy offers a chance to see a combination of spectacular scenery, traditional towns and epic natural wonders. One minute you’re exploring the ancient ruins of Pompeii, the next you’re driving along the heart-stopping roads of the Amalfi Coast.

You could spend a few days exploring Puglia’s prettiest towns including Monopoli and Ostuni, before spending the rest of the week enjoying the crystal waters in Sicily.

Stand up paddle boarding in Sicily
Stand up paddle boarding in Sicily

There’s a variety of cuisines to sample too, with incredible pizza in Naples, seafood pasta in Puglia, tasty olive oil and Sicilian delicacies including arrancini and sweet cannolis.

Oh and you’ve got a mix of activities on offer too. Hike active volcano Stromboli in Sicily, take a boat trip to the glamorous island of Capri, stay in a traditional Trulli house in Alberobello or go on a pizza tour of Naples (it’s a hard life!)

And the best part about a southern Italy road trip? The fact you don’t have stick to a set route. While you could follow my southern Italy itinerary on the map below, I’d encourage you to read my travel tips and then add a few stops of your own. It’s a beautiful part of the country – you could find yourself passing fields of olive trees or winding along dramatic cliff roads. You never know what you’ll find!  

Rather than create one epic Italian road trip, I’ve divided the country in two! Read on for my southern Italy road trip or check out my route for an amazing northern Italy road trip, which includes stops in Rome, Verona, Venice, Lake Como and a few other beautiful spots. 


Southern Italy Road Trip Itinerary

This south of Italy road trip starts in Naples and ends in Sicily – both of which have plenty of flight options available. Italy self-drive holidays are growing in popularity, and it’s easy to see why with routes like this one!

From eating pizza in Naples, to feeling like a movie star as you drive the Amalfi Coast, and then onto some of the prettiest towns in Italy as you explore Puglia, before finishing your enjoying Sicily’s dramatic landscapes, this route has it all! It’ll definitely show you some of the most beautiful landscapes in Italy too.

It’s also an easy one to break up – you could just concentrate on Naples and Amalfi, or spend a week exploring Puglia. These are some of my favourite parts of Italy, so I’m excited to share why they should be on your Italy road trip itinerary. I’d recommend a minimum of one week in southern Italy, but if you want to cram in everything on this blog, I’d suggest two to three weeks.

I’d also recommend taking a look at my guide to the best hidden gems in Italy too – you might find a few other stops to visit while you’re touring southern Italy.

Southern Italy Road Trip Map

I’ve used a map to plot the perfect route for your Southern Italy road trip. I recommend opening it another window to study in detail!

What to pack for your road trip

If you’re wondering what to pack for your trip, this guide to road trip essentials has you covered. From portable chargers to ways to stay entertained on long journeys, it’ll help you create your road trip packing list.

Southern Italy Road Trip: Stop 1 – Naples

Once you’ve exhausted northern Italy, it’s time to head south on your Italy road trip. The unspoilt shores of the southern coastline will appeal to travellers who like to explore off the beaten track.

First up, the bustling streets of Naples. Set on the Mediterranean coastline with active volcano Mount Vesuvius as its backdrop, this exciting city is the birthplace of Italian pizza, mysterious underground catacombs, castles and lively main squares.

Naples, Italy
Naples, Italy (with Vesuvio National Park as its backdrop)
Coffee overlooking Naples and Vesuvius
You could be sipping coffee with views of Naples and Vesuvius as you travel southern Italy

If you choose to stay in Naples for a few nights, you could take day trips to the Amalfi Coast, hop on a boat to the island of Capri or tour Pompeii’s archaeological sites. There are lots of amazing southern Italy tours to choose from!

Naples to the Amalfi Coast (town of Amalfi): 70km / 1 hour 24 mins approx.

Southern Italy Road Trip: Stop 2 – Amalfi Coast

If your idea of the perfect Italy road trip is immersing yourself in glitz and glamour of old-time Italy, the Amalfi Coast is for you. With cliffside villages, colourful buildings and secluded beaches which lead to the sparkling Tyrrhenian Sea, it’s one of the most beautiful places I’ve visited in Italy. It’s also known for being one of the best Italian road trips.

Brace yourself if you’re the designated driver! The coastal road is winding and not for the faint hearted, but the views are worth it. Don’t miss the picturesque towns of Praiano, Ravello, Sorrento and Positano – a classic holiday resort with an old-world grandeur and panoramic views along the coast.

Vietri Sul Mare - Amalfi Coast, Italy
Vietri Sul Mare – lots of people adore this Amalfi Coast road trip

If you plan to stay a few nights, Sorrento is a good choice. With museums, piazzas, shopping and reasonably priced accommodation on offer, it’s a great base from which to explore the towns along the coast and visit the island of Capri. I’d recommend reading this guide to where to stay in Sorrento during your trip planning!

Amalfi Coast - a beautiful stop on a southern Italy road trip
The Amalfi Coast is one of the best places to visit southern Italy

I did some of this road trip in reverse last summer and ended in Amalfi Coast before driving to Naples and fly home. We booked a last minute night at one of the hotels in Vietri Sul Mare, a town close to Salerno, right at the start of the coast. It was a basic hotel, but I still dream about the views regularly – looking out over that incredible blue water and the beautiful town and beach. I’d go back in a heartbeat! 

Amalfi Coast to Puglia (town of Monopoli): 307km / 3 hours 46 mins approx.
Vietri Sul Mare - Amalfi Coast, Italy
Vietri Sul Mare – Amalfi Coast, Italy – a must see on a south Italy road trip

Southern Italy Road Trip: Stop 3 – Puglia

Puglia is where we chose to go on our main holiday last year. Similar to this southern Italy travel itinerary, we hired a car in Naples and drove across the country to Italy’s heel. Driving in southern Italy wasn’t too scary, although some of the smaller towns and villages have narrow roads, so I’d recommend hiring a compact car. 

Puglia is pretty, traditional, and has a great reputation for food. It’s one of my favourite parts of Italy. Home to unspoilt sandy beaches and cliffside fishing villages, Puglia is often overlooked in favour of glam places like Amalfi or Cinque Terre, but I think it offers a lot.

Alberobello - a must visit on a southern Italy road trip
Alberobello – a must visit on a southern Italy trip itinerary

You could spend a few weeks just in Puglia, and still have plenty more to go back for, as there are gorgeous beaches, pretty towns and lots of history to keep you busy!  A few places I’d recommend visiting are Alberobello, with its traditional white, cone-shaped Trulli houses (which, collectively have been named a UNESCO World Heritage Site). We spent a night staying in one and it was absolutely magical.

Exploring Alberobello in Puglia, Italy
Exploring Alberobello in Puglia, Italy – a must on your south of Italy itinerary

We also stayed in Monopoli – a beautiful seaside town with a small beach, medieval city walls and maze-like cobbled streets fulled with tiny wine bars and rustic restaurants.

Polignano a Mare is one of the most famous towns, and another absolutely stunning spot. With it’s cove like beach, dramatic cliffs and even a cave restaurant built into the rocks overlooking the water, I fell in love with the place! We spent a day there, eating fresh seafood pasta and gelato while meandering the pretty streets.

Polignano a Mare - a must see on your Italy road trip
Polignano a Mare – a must see on your Italy road trip
Polignano a Mare - a must see on your Italy road trip
Polignano a Mare is one of the best best places to visit in southern Italy

Ostuni is another must-see (and one of the best hidden gems in Italy). It’s known as the white city, and from afar has the appearance of lots of white houses stacked up on top of each other. Park somewhere outside the old city and wander up the hill, taking in the magic of the white washed buildings, cute pizzerias and architectural wonders. 

If you’re planning a trip to Italy and interested in discovering Baroque architecture as well as having lively nightlife, street food and café lined piazzas, venture to Lecce, one of Puglia’s largest cities. Or consider a trip to Bari or Gallipoli – both great stops on your Puglia road trip. If you’re having trouble choosing where to stay, check out the 11 best luxury villas in Puglia.

Puglia to Sicily (town of Taormina): 486km / 6 hours 9 mins approx.
Ostuni, Puglia, Italy
Ostuni, Puglia, Italy
Ostuni, Puglia, Italy
Ostuni is a beautiful place to visit on your Italy self-drive holiday

Southern Italy Road Trip: Stop 4 – Sicily Itinerary

As you can see, the drive from Puglia to Sicily is a long one. You could do it in a day, but you might be more comfortable breaking it up over a few nights. The fastest ferry route to Sicily is from Reggio Calabria and it takes around half an hour.

This is one of the best parts of the itinerary, so there’s a chance you may want to book a dedicated holiday for your Sicily road trip, as there’s so much to see and do. Adventure lovers might want to climb Mount Etna. Over 3500m high, you can get pretty high up with minimal effort, as there’s a cable car to get you up to 2500m!

Views of Etna from Taormina, Sicily
Views of Etna from Taormina – a great stop on this southern Italy and Sicily itinerary

In terms of beauty, Taormina is one of the prettiest hilltop towns in Sicily. It’s home to a theatre built by the ancient greeks, several historic churches, and pretty streets filled with colourful market stalls and restaurants.

It’s also a gorgeous region for hotels, with everything from cute boutique hotels to grand resorts. My guide to the best beach resorts in Sicily will help you pick where to stay!

Taormina coastline - a perfect place to finish your southern Italy road trip itinerary
Taormina coastline – a perfect place to finish your southern Italy road trip itinerary

Nature lovers will enjoy bird-spotting in the reserves, or you can spend time enjoying the sandy beaches of picturesque Cefalu or Mondello.

Taormina, Sicily
Taormina – one of the best south Italy holiday destinations
Cefalu, Sicily
Cefalu, Sicily – a highlight included in many Italy travel guides

It doesn’t seem long ago that I spent a week sailing around Sicily’s Aeolian Islands – something I’d recommend in a heartbeat if you have a bit longer to spent in the region. I hiked Stromboli Volcano, took a mud bath on Vulcano island, and went wine tasting in Salina. The islands are gorgeous, varied and have a wonderful old world charm that I found very comforting.

Hiking Stromboli Volcano, Sicily
Hiking Stromboli Volcano, Sicily
Sailing around Sicily with MedSailors
Sailing around Sicily with MedSailors – one of the top things to do in south Italy
Wine tasting experience at Hauner Winery, Sicily
Wine tasting experience at Hauner Winery, Sicily – a great addition to your southern Italy vacation itinerary

When Is The Best Time To Visit Southern Italy?

Italy has a Mediterranean climate and is a lovely destination to visit all year round.

Temperatures vary by region, but as a quick example, you can expect average temperatures of around 0°C in around Cortina (a ski resort in the mountains) in January, and as high as 37°C in July in cities such as Milan and Venice. Temperatures in the south remain mild in winter, making destinations like Puglia and Sicily great options for a winter holiday.

If you’re wondering when is the best time to visit southern Italy, I’d suggest planning a trip between April and June, or in September or October, just after the peak summer season.

The weather tends to be consistent in these months, but isn’t too hot. Plus, as you’re missing peak season, you should benefit from lower prices and fewer people.

I hope you’ve enjoyed my southern Italy road trip itinerary. Let me know where you decide to go and what your highlights are! As mentioned, this is probably best spread out and followed at a slower pace, so if you’re looking for a southern Italy itinerary for 14 days, it’s ideal!

Looking to explore more of the country? Check out my northern Italy road trip itinerary

I honestly think this is the best south Italy itinerary as it’s got a bit of everything. If you want to save it to help with your trip planning, how about pinning it for later… 

The ultimate southern Italy road trip

1 thought on “The Ultimate Southern Italy Road Trip: Routes, Sights, Guides, Maps And More”

  1. I haven’t been to Italy since I was a teenager! Now I’m trying to figure out why it’s hasn’t been higher up my list?? Those pictures make me want to be there now! Thanks for the inspiration and the tips! ?


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